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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease polycystic ovary syndrome
Comorbidity C0011860|type 2 diabetes
Sentences 5
PubMedID- 22778733 There is a high prevalence of pcos in women with type 2 diabetes mellitus, and there is evidence that insulin resistance and associated compensatory hyperinsulinaemia play a central role in the pathogenesis of pcos in some women [4–7].
PubMedID- 22536232 An elevated risk profile for cardiovascular morbidity was demonstrated in pcos patients, mainly attributed to increases in type 2 diabetes, dyslipidemia, and hypertension [18, 26, 27] which might constitute a cofounder when studying the correlation between hyperandrogenism and the risk of metabolic syndrome in pcos.
PubMedID- 26217407 Key messages: ovulatory dysfunction is the most common female cause of infertility in the uk.polycystic ovarian syndrome is associated with oligo-ovulation and type 2 diabetes.good glycaemic control is essential before getting pregnant to prevent congenital malformations and miscarriages in young women with type 2 diabetes.metformin is safe in the first trimester and reduces the rate of miscarriages and gestational diabetes.labetalol, methyldopa and hydralazine are deemed safer in pregnancy.women should not conceive on statins due their potential teratogenic effects.
PubMedID- 21920943 Impaired insulin-mediated glucose uptake (imgu), is a major risk factor for type 2 diabetes in women with polycystic ovary syndrome (pcos).
PubMedID- 24843673 pcos is frequently associated with type 2 diabetes mellitus; however, it is unknown whether pcom and pcos are prevalent in japanese patients with type 1 diabetes mellitus.

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